Yes. Two separate studies examined the safety of C.E.T.® VEGGIEDENT® FR3SH® and eggshell membrane in dogs:

• In adult dogs, C.E.T.® VEGGIEDENT® FR3SH® chews are well tolerated at 1x and 5x the recommended dosage when given by spontaneous oral ingestion.
• The eggshell membrane product was found to be safe at up to 5x the recommended dosage — the targeted margin of safety.